Associate Professor (713) 677-7582 Room: 416 lmitchell@ibt.tamus.edu Genetic Epidemiology of Birth Defects and Cancer.

:: Research / Professional Interests

Dr. Mitchell is a joint faculty member, located at Institutes for Biosciences and Technology.

:: Education

Yale University, New Haven, Connecticut
Ph.D. (1991) in Chronic Disease Epid.
University of Pittsburgh, Pittsburgh, Pannsylvania
M.S. (1985) in Genetic Counseling
State University of New York at Stony Brook, Stony Brook, New York
B.S. (1983) in Biological Sciences

:: Career History

:: Teaching Responsibilities

No Information available at this time, please check back for updates.

:: Recent Grants

• Velocardio-facial syndrome-Molecular and Clinical Studies. Children's Hospital of Philadelphia 5 P01 DC02027-08, 2002-2003.
• Pharmacogenetic Epidemiology of Birth Defects and Cancer. NIH-Univ. of Pennsylvania 1 R21-ES-11658-01, 2002–2004.
• The Genetics of Spina Bifida. NIH-NICHD (NIH) 7 R01 HD039195, 2003-2004.
• Maternal, Fetal and Environmental Causes of Birth Defects. NIH-NICHD 7 R01 HD039081, 2003-2004.

:: Recent Publications

1. Mitchell LE. Genetic epidemiology of birth defects. Epidemiol. Rev. 19:61-68, 1997.  (Invited review)
2. Mitchell LE, Christensen K. Evaluation of family history data for Danish twins with nonsyndromic cleft lip with or without cleft palate. Am. J. Med. Genet.  72:120-121, 1997.
3. Mitchell LE. Differentiating between fetal and maternal genotypic effects using the transmission test for linkage disequilibrium. Am. J. Hum. Genet. 60:1006- 1007, 1997.
4. Goldmuntz E, Clark BJ, Mitchell LE, Jawad A, Cuneo BF, McDonald-McGinn D, Chien P, Feuer J, Zackai EH, Emanuel BS, Driscoll DA. Frequency of 22q11 deletions in patients with conotruncal defects. J Am Coll Cardiol 32: 492-498, 1998.
5. Wyszynski DF, Mitchell LE. Report of the newly formed international consortium for oral clefts genetics. Cleft Palate J 36:174-178, 1999.
6. Treloer SA, Macones G, Mitchell LE, Martin NG. Genetic influences on premature paturition in an Australian twin sample.  Twin Research 3:80-82, 2000.
7.  Emanuel BS, Budarf M, Shaikh T, Goldmuntz E, Driscoll D, Mitchell, L. Blocks of duplicated sequence define the endpoints of DGS/VCFS 22q11.2 deletions. In: Etiology and Morphogenesis of Congenital Heart Disease: Twenty years of Progress in Genetics and Developmental Biology. Clark E, Nakazawa M, Takao A, eds. Futura Publishing Company, NY.  2000.
8. Mitchell LE, Beaty T, Lidral A, Munger R, Murray JC, Saal HM, Wyszynski DF. Guidelines for the design and analysis of studies on non-syndromic cleft lip and palate in humans. Summary report from a workshop of the International Consortium for Oral Clefts Genetics. Cleft Palate Craniofacial Journal.  Cleft Palate Craniofacial Journal  39:93-100, 2002.
9. Mitchell, LE. The relationship between case-control studies and the transmission disequilibrium test.  Genet Epidemiol 19:193-201, 2000.
10. Mitchell LE, Murray JC, O'Brien S, Christensen K. Evaluation of two putative susceptibility loci for oral clefts in the Danish population. Am J Epidemiol. 153:1007-1015, 2001.
11. Underkoffler LA, Mitchell LE, Localio AR, Marchegiani SM, Morabito, Collins JN, Oakey RJ.  Molecular analysis of nondisjunction in mice heterozygous for a Robertsonian translocation.  Genetics, (in press.) 
12. Mitchell LE. Genetics of Cleft Lip and Palate: Mode of inheritance of oral clefts. In: Wyszynski DF, ed. Cleft Lip and Palate: From Origin to Treatment. Oxford University Press.  (In press.)
13. Mitchell LE. Twin Studies. In: Wyszynski DF, ed. Cleft Lip and Palate: From Origin to Treatment. Oxford University Press.  (In press.)