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Professor
Acting Chair of Biomedical Sciences
(214) 828-8272
Room: 401A
bhinton@bcd.tamhsc.edu
Regulation of Proliferation and
Differentiation in the Mandibular Condylar Cartilage, Hormonal
Influences on Craniofacial Growth. |
 The focus of my career has been the temporomandibular joint (TMJ), first
in human skeletal material, then in experimental animal studies.
Early
on, my experimental studies centered on the structural, proliferative,
and synthetic response of the intraarticular structures of the TMJ
to a change in jaw function, as variously induced by dietary consistency,
condylar fracture, and postural changes.
More recently, my interests
have shifted to elucidation of the unique structural and growth properties
of the TMJ cartilage, a secondary cartilage with developmental differences
from limb cartilages, as reflected in its responsiveness to growth
factors and hormones and its extracellular matrix composition.
present
research directions include: 1) molecules important for regulation
of proliferation and differentiation in chondroprogenitor/ osteoprogenitor
cells 2) influence of growth hormone (GH) on growth of the craniofacial
skeleton as reflected in GH-deficient dwarf rats, and 3) interaction
of GH and mandibular posture in the regulation of condylar cartilage
proliferation and mandibular growth.
University of Michigan, Ann Arbor, Michigan
Postdoctoral followship (1980-1983) Anatomy & Craniofacial
Biology
University of Michigan, Ann Arbor, Michigan
Ph.D. (1979) Biological Anthropology
University of Michigan, Ann Arbor, Michigan
M.S. (1975) Anthropology
University of Tennessee, Knoxville, Tennessee.
B.S. (1968) Nuclear Engineering
2003-present
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Acting Chair, Department of
Biomedical Sciences, Baylor College of Dentistry, Texas
A&M University System Health Science Center |
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| 1999-2003 |
Associate Chair, Department
of Biomedical Sciences, Baylor College of Dentistry, Texas
A&M University System Health Science Center |
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| 1994-present |
Faculty, Center for Craniofacial
Research & Diagnosis, Baylor College of Dentistry, Texas A&M
University System Health Science Center |
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| 2004-present |
Professor, Department of
Biomedical Sciences, Baylor College of Dentistry, Texas
A&M University System Health Science Center |
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| 1992-2004 |
Associate Professor, Department
of Biomedical Sciences, Baylor College of Dentistry, Texas
A&M University System Health Science Center |
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| 1988-1992 |
Associate Professor, Department
of Anatomy, Baylor College of Dentistry |
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| 1983-1988 |
Assistant Professor, Department
of Anatomy, Baylor College of Dentistry |
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| 1982 |
Lecturer, Medical Gross Anatomy, Department of Anatomy and Cell
Biology,
University of Michigan |
Tau Beta Pi (Engineering Honorary), elected 1967
National Research Service Award (NIDR-NIH), 1981-1983.
Gross Anatomy (dental), Integrated Biomedical Sciences (dental hygiene),
and Advanced Craniofacial Growth and Development (graduate). Dr. Hinton
is the coordinator of undergraduate teaching for BMS.
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Expression of Growth Factors and Their
Receptors in Mandibular Condylar Cartilage in Response to Biomechanical
and Hormonal Stimuli.
 (File
Size: 54 KB) American Association of Orthodontists Foundation
Biomedical Research Award, 1999-2001.
- Regulation of Mandibular Condylar Cartilage
Growth. (File
Size: 48 KB) NIH-NIDCR R01 DE 015401-01, 2003-2007.
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Hinton RJ, Carlson DS. Effect of function
on growth and remodeling of the temporomandibular joint. In: McNeill
C, Hannam A, Hatcher D, eds. Occlusion: Science and Practice.
Quintessence: Carol Stream, Illinois, pp. 95-110, 1997.
- Del Santo M. Jr., Marches F, Ng M, Hinton RJ. Age-associated
changes in decorin in rat mandibular condylar cartilage. (File
Size: 3.31 MB) Archs. Oral
Biol. 45(6): 485-494, 2000.
- Fuentes MA, Opperman LA, Bellinger LL, Carlson
DS, Hinton RJ. Regulation of cell proliferation
in rat mandibular condylar cartilage in explant culture by insulin-like
growth factor-1 and fibroblast growth factor-2. Archs. Oral
Biol., 47(9): 643-654, 2002. (File
Size: 376 KB)
- Fuentes MA, Opperman LA, Buschang P, Bellinger LL,
Carlson DS, Hinton RJ Lateral functional
shift of the mandible: Part I. Effects on condylar cartilage
thickness and proliferation. (File
Size: 126 KB) Am.
J. Orthod. Dentofac. Orthoped. , 123:153-159, 2003.
- Fuentes MA,
Opperman LA, Buschang P, Bellinger LL, Carlson DS, Hinton
RJ Lateral
functional shift of the mandible: Part II. Effects on gene expression
in condylar cartilage. Am.
J. Orthod. Dentofac. Orthoped. , 123: 160-166, 2003. (File
Size: 207 KB)
- VandeBerg
JR, Buschang PH, Hinton RJ Absolute
and relative growth of the rat craniofacial skeleton. Archs.
Oral Biol., 49: 477-484, 2004. (File
Size: 215 KB)
- VandeBerg JR, Buschang PH, Hinton
RJ Craniofacial
growth in growth hormone-deficient rats. Anat. Rec.,
278A: 561-570, 2004. (File
Size: 282 KB)
- Hinton RJ, Carlson DS. Regulation of mandibular
condylar cartilage growth. Sem. Orthod., in press.
- Buschang PH, Hinton RJ. Gradients of potential
for modifying craniofacial growth. Sem. Orthod., in press.
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